The two- and three-bedroom family houses, backed by national housebuilder Gleeson, will be located on a 1.9ha site adjacent to the Grade II*-listed building, dubbed Manchester's 'answer to the Taj Mahal'.
According to Gleeson the development is the first in the UK to use aspects of 'sacred geometry' as a basis for its masterplan, due to its proximity to Pugin's monastery.
Regeneration group New East Manchester's chief executive Tom Russell said: 'Bringing high-quality family homes to this part of east Manchester sends out a very clear message that this area is undergoing a significant transformation and we have great confidence in its future.
'We have designed this scheme to sit respectfully next to, and enhance, the historic monastery building and reflect the wider Gorton area. Creating an innovative new urban village with very high standards of architectural design is incredibly exciting.'
Pugin's 1863 landmark is currently being restored, after new drawings were found of it by E W Pugin's stepbrother Peter Paul Pugin. The restoration will end decades of neglect.
Work on the housing development is likely to start in the autumn.