The project will feature four towers, ranging in height from eight to 40 storeys, which will be built on a former industrial site at 22 Marsh Wall.
Grouped around a central piazza, the development will provide around 700 new homes as well as offices and community facilities.
According to a spokesman, the pair of eight-storey blocks has been designed to 'relate to the smaller-scale residential developments' to the south of the scheme.
Meanwhile the 27- and 40-storey skyscrapers on the northern side will look towards the high-rises in West India Dock and the cluster of towers at Canary Wharf.
The project will boast a number of environmental measures, including a biomass heating plant, 740m 2of solar panels, and 'biodiverse' roofs.