Architecture+Design Scotland will officially take up its brief - 'to challenge and inspire excellence in the built environment' - from midday.
The organisation - which replaces the old Royal Fine Art Commission for Scotland - will carry out many of the same functions as CABE, including an extensive Design Review programme.
Sebastian Tombs, new chief executive of Architecture+Design Scotland, said it would aim to make a real difference.
'The most successful small countries place high value on their buildings and on the spaces between them,' he said. 'They recognise that good buildings and public spaces enhance the quality of life for citizens and visitors.
'If we are to 'raise our game' as a country, we too need to ensure that we have a built environment to match the natural environment that attracts visitors and provides a high quality of life,' Tombs added.