Developer Larry A Silverstein has asked the architect to draw up plans for a massive 185,000m 2skyscraper at 175 Greenwich Street - a project which has been dubbed the Tower Three scheme.
Working within the Daniel Libeskind 'Ground Zero' masterplan, Rogers will join fellow Brit Norman Foster, who is drawing up proposals for Tower Two, and Japanese big-hitter Fumihiko Maki, who has just been handed the design of Tower Four.
The news comes less than two months after Rogers flew to New York to allay fears over his connections with the political group Architects and Planners for Justice in Palestine to save his multimillion-pound Jacob K Javits Convention Center job.
The Ground Zero project will be Rogers' fourth in the American city, where he is also involved in the Silvercup Studios redevelopment in Long Island City, Queens, and a $200 million (£100 million) revamp of the lower Manhattan waterfront.
Rogers said: 'It is a rare opportunity to have been appointed to design one of the new buildings on this key site in New York, and we are particularly delighted that we will be working in the heart of the city.
'This will be a complex and challenging project - but one which will also help to contribute to the revitalisation of New York City and which will help to inspire a new hope for the city's future.'