Overlooking the East River, the $1 billion (£0.6 billion) project will provide eight new soundstages for Silvercup Studios Associates - the television and film studios where hit shows like The Sopranosare made.
The 185,000m 2development south of Queensboro Bridge also includes proposals for 1,000 homes, commercial space, a catering hall and a new plaza.
Part of the scheme involves restoring the New York Architectural Terra-Cotta Company building, a local landmark built in 1892.
'[We] are creating a 24/7 live, work and leisure community,' said Stuart Suna, the president of Silvercup Studios. 'The public will enjoy new restaurants and retail opportunities, while having a magnificent view of the Manhattan skyline.'
The development, which could start on site as early as next year, will also boast a range of 'green' features such as grey-water retention and a sedum roof.