The long-awaited cb1 project, which is being masterminded by the Ashwell Property Group, aims to transform 9.6 ha of land around the city's station into a new gateway destination.
Rogers, who taught in Cambridge, will design all the 'statement buildings and public realm' on the site - parts of which have remained derelict for nearly 50 years.
He said: 'The entrance to Cambridge, one of the world's most beautiful cities, is in dire need of urban regeneration. This is a remarkable opportunity to design a dynamic urban environment and create an entirely new gateway to Cambridge.'
As well as creating 1,000 new homes, the scheme will also include, office and retail space, a historical research and cultural centre, a hotel and a health clinic.
Masterplans for the project were submitted to Cambridge City Council towards the end of last year, and phase one of the scheme, a new 8,000m 2commercial building worth £18 million, is set to get under way in February 2006.