The £725 million regeneration project was rejected because of perceived concerns about the height of the project and the possible overdevelopment of the site.
Drawn up for the Ashwell Property Group, the long-awaited scheme in south-east Cambridge would have delivered 1,000 new homes as well as a mass of office and retail space.
The project - which would also have included a batch of 10-storey commercial buildings - was savaged by CABE two weeks ago.
Both architect and developer have insisted that they will stay on the project, amending the designs for a fresh planning application.
But at least one long-term observer of the Cambridge scene told the AJ that local councillors and campaigners would do 'all they could to kill off the scheme'.
However, Rogers director Andrew Morris refused to be put off by the bad news from the council.
'Despite the council's decision to refuse planning permission for the scheme, we still feel it has a large number of inherent design strengths, as well as meeting many of the aspirations contained in the council's vision for the site,' Morris said.
'I am hopeful that, through discussions with Ashwell and the council, a consensus can be reached on a scheme which will deliver the much-needed regeneration of the area and provide a new, distinctive quarter for Cambridge in the future,' he added.