The 1ha development for Cheltenham-based Satnam Investments signals Reid's first significant foray into Manchester.
It features 500 apartments, 3,200m 2of offices and 630 parking spaces and is earmarked for St Michael's Flags and Angel Meadow - a notoriously run-down area of the city.
In a bid to smooth its passage through planning, the development has been contoured to blend in with its landscape, which features in a number of LS Lowry paintings.
It is split into three 'fingers' rising in height from the banks of the River Irk at its south eastern boundary towards a 60m-high point at the northernmost end. The project also makes use of landscaped gardens and roof terraces overlooking the city.
Manchester City Council is expected to announce its decision in early June.