An email petition has been launched calling for opposition to Dixon Jones' plans to demolish 'most' of the Soho landmark - built in by Henry Tanner in 1915 - and construct a mixed-use retail and office complex.
The Regent Palace scheme has been embroiled in controversy since Allies and Morrison first proposed redeveloping a large swathe of London's Regent Street in 2004.
The Twentieth Century Society and SAVE Britain's Heritage launched savage attacks on the plans to pull down the hotel and the proposals for its replacement.
Dixon Jones replaced Allies and Morrison on the controversial scheme in January 2005. A year later the hotel closed when operator decided the condition of the building and the scale of investment needed for repairs and upgrading it were unfeasible.
Dixon Jones was unavailable for comment at the time of going to press.