At the heart of the 15-volume, 10,000-page document are plans for new sporting venues, highways, bridges, river works, utilities, parks, open spaces, and the post-Games reconfiguration.
As announced last year, there have been changes to the masterplan since winning the bid and this new planning application now reflects these.
Changes include: better integration of the Olympic Village with the Stratford City Development; relocating the International Broadcast Centre and main Press Centre to within the Park boundary; and providing a more compact layout of venues and Park facilities for Games time and legacy use.
Speaking this morning at the ODA headquarters in East London, David Higgins, the ODA's chief executive, said: 'The planning applications represent a significant moment in delivering our vision for the Olympic Park and creating a benchmark 21st Century urban environment.
'The Games are the catalyst for much needed social, environmental and physical regeneration of a deprived area of East London - the Lower Lea Valley - and the sheer size and scope of the application reflects both the scale of the challenge as well as the enormous opportunity hosting the Games will bring to this area.
'We are 'locking-in legacy' at a very early stage - five and a half years before the Games begin - and we now move from the planning phase to the next stage of the Olympic Park project, what we are calling 'Making the Park 3D - Demolition, Dig and Design' - which will take us to Beijing.'