Called Falling Waters, in a misspelled nod to Wright's own work, the family home is so named because of its proximity to Newcastle's Jesmond Dene park and its waterfall.
Estate agent Sanderson Young believes the building will attract interest on a national level thanks to its distinctive design and special features.
The 600m2 home boasts a concealed cocktail bar, a 'Spanish-themed' dining room and a sunken lounge complete with a 14-seat 'conversation pool'.
Sanderson Young managing director Duncan Young believes the great selling point of the house is that it has remained untouched.
He said: 'Usually, houses of this period have been demolished or altered substantially, but that's not the case with Falling Waters.
'This house was under construction for more than two years in 1973 and has been owned by the same person since.
'It's just astonishing to walk around the property and see the very best of those years in terms of architecture and design all around you in every room,' he added.