Developer Project Abbey took on Ken Shuttleworth's practice yesterday, hours after winning a bidding war for the mammoth Middlesex Hospital site in Fitzrovia.
The practice, which has grown dramatically over the last two years, will now draw up a masterplan for the 1.2ha site.
As it stands, Make has only one completed scheme to date, but continues to win work with exceptional frequency.
The firm will work with high-end development firm Candy and Candy, who will oversee the project, with a particular focus on the interiors.
Richard Williams, chief operating officer of CPC, which part-owns Project Abbey, said he was excited by the development.
He said: 'We are delighted to have purchased the site and look forward to working closely with Ken Shuttleworth and Make.
'We will create a mixed-development scheme out of the existing fabric that will rejuvenate the existing area.'