Titled Back to the Future, the huge show at Edinburgh's Dean Gallery will have more than 200 exhibits, beginning with some of Spence's award-winning student pieces from the 1920s.
Back to the Future looks at the full range of Spence's work, from nuclear power stations and airports, to the first of Scotland's new university complexes and his world-famous Coventry cathedral (1951).
The exhibition will also showcase many previously unseen items from the Sir Basil Spence Archive, recently gifted by the Spence family to the Royal Commission on the Ancient and Historic Monuments of Scotland (RCAHMS).
Timed to coincide with the centenary of the birth of one of Scotland's most famous architects (1907-76), the comprehensive show will be complemented by a smaller, touring exhibition.
Supported by the Heritage Lottery Fund, the Arts and Humanities Research Council and the Scottish government, the exhibition opens on 19 October.