The £20 million scheme will boast 228 bedrooms in two 'splayed' wings - one a nine-storey building facing out on a new public square, the other an eight-storey block looking onto Shudehill.
Sitting on a double-height, glazed plinth, the hotel replaces an existing three-storey building on the key 0.32ha junction plot and falls within the area masterplan drawn up by fellow Mancunians MBLC.
The accommodation blocks will be clad in a grey concrete-resin rain-screen system.
According to the design statement, the proposal 'has been developed with a clear understanding that it must address and reinforce this prominent corner of the site'.
The statement continues: 'The new development will be seen from all sides and our design philosophy recognises this.'
The project, which is already on site, is due to be finished by autumn 2007.