The building, which was the pinnacle of Johnson's Modernist phase, was his private residence until he died in 2005.
The Glass House has since been taken over by the USA's National Trust, which has carried out an extensive renovation programme.
It sits on a 19ha site which includes 14 structures, a major collection of contemporary art, and a meticulously sculpted landscape.
Before Johnson's death in 2006, David Whitney, a renowned art collector, curator, art advisor, and Johnson's long-time partner, directed his estate to support the National Trust's preservation and programming of the Glass House.
Richard Moe, president of the National Trust for Historic Preservation said: 'We are deeply indebted to Philip Johnson, for donating his masterpiece to the National Trust, and to David Whitney, whose generous bequest has secured a vibrant future for the Glass House.
'The National Trust's stewardship of the Glass House will honour the wishes of these two men by ensuring that it remains an innovative centre for people interested in modern architecture, and a central place for people who care about art, design, landscape and preservation.'