The UK firm was selected ahead of a number of internationally-renowned firms, and will be responsible for enhancing the area around the world trade tower.
The project - which represents one of the practice's largest ever projects - will include a state-of-the-art convention centre, offices, residential towers, hotels and hotel apartments as well as commercial facilities.
Hopkins will be developing a 130,000m 2mixed-use site, which will incorporate the Landmark Tower, situated on the Sheikh Zayed Road, adjacent to the Emirates Towers.
Helal Saeed Al Marri, director general of the Dubai World Trade Centre, said: 'Our aim is that this first phase of the masterplan will incorporate iconic design and inspiring architecture. To this end, we have selected the world's leading companies to help us achieve our goal.'
'We are confident the architectural plans they [Hopkins] are developing will contribute to the creation of one of the world's leading business districts, at the heart of Dubai.'