Green Party assembly member Jenny Jones will ask the mayor why he has not addressed the site's potential for aiding transport via the Grand Union Canal this week, and will be answered in writing on 28 February.
Isis Waterside Regeneration's plans for the site - which includes 922 residential units and 7,500m 2of office space designed by Jestico + Whiles and CZWG - are currently being considered by Hounslow Borough Council.
There is a policy in the London Plan to increase the use of the Blue Ribbon Network, which includes Commerce Road, for waterborne transport. The Blue Ribbon Network policy was introduced specifically to protect the capital's waterways from unsuitable development.
Jones said: 'I want to get lorries off London's roads to make streets safer and air cleaner. The canal network has huge untapped potential for moving freight in London. Brentford is an essential part of London's navigable waterways. Many of its navigation facilities have recently been built over for housing and retail.
'The Commerce Road site, with its existing covered wharf, would be ideal for waterborne freight. Hounslow council and the London mayor must ensure it is protected for navigation,' she added.