The 2ha development on Manchester Road will feature a 20-storey residential tower housing 800 flats, a 120-bedroom hotel and a 1,500 capacity banqueting hall.
The new £130 million scheme will stand on the site of the demolished Reyner House complex - an unloved 1960s block.
Working with Asquith Properties, the practice also plans to create new footpaths, cycle ways and public spaces.
It is understood the project will be split into four phases, and the first residents are expected to move in by the end of 2010.
The winning proposals were selected by local regeneration agency Trident, and a planning application is due to be submitted within the next few months.