The scheme, backed by developer First Base, is on the fringes of the wider redevelopment of the Elephant and Castle area, currently being masterplanned by Make Architects.
The development, built on a former coal store and printing facility, will provide 164 new homes, 42 per cent of which will be more widely affordable, as well as key-worker housing and properties for rent and for sale.
According to First Base additional commercial space will be created and allocated for small businesses. The scheme has been submitted alongside another First Base project in Islington, north London, designed by Porphyrios Associates and John Robertson Architects.
First Base managing director Eliot Lipton said: 'Printworks and our Holloway Road project in Islington are two of many exciting developments in the First Base pipeline, and we look forward to continuing to create thriving mixed-tenure communities that bring together First Base's core propositions of design, quality and sustainability.'