The Los Angeles-based architect is understood to be designing six 'exclusive' ranges, as well as a set of 'tabletop items'.
Describing the collection, Gehry said: 'In conceptualising designs for Tiffany, I worked as I always do, sketching and creating models.
'Sculptors and painters have inspired me with their ability to make things with their own hands.'
He added: 'This process led to the discovery of new ways to give feeling and spirit to form, and realise our shared vision jewellery that provides a beautiful context for living now.'
It is not the first time the American has tried his hand at designing other products. Last year the architect teamed up with the Massachusetts Institute of Technology's Media Lab to draw up plans for a prototype car that could change colour according to the driver's mood (AJ 29.07.04).
The new Gehry jewellery will be unveiled at Tiffany & Co's American and Japanese stores in April.
The European launch is not expected until the autumn.