The £24.5 million scheme is one of the first projects to get under way as part of Will Alsop's masterplan for the South Yorkshire town.
Designed in collaboration with Arup, the interchange will combine Barnsley's north and south bus stands and will provide access to the existing rail link.
Clare Ailward, the architect behind the scheme, said: 'The project will provide a high- quality, fully enclosed public transport passenger environment comprising a bus and coach concourse, passenger facilities, retail and offices.'
The scheme will also feature a first floor pedestrian bridge to the rail station, an EFTE canopy roof and a series of commercial 'pods' which will face onto the town centre.
Ailward added: 'The extensive us of natural pre-patinated copper on the roof, bridge and sculptural feature - a focal point at the lower end of Regent Street, is hoped to give the new Interchange prominent character in the heart of Barnsley.'
Built for the South Yorkshire Passenger Transport Executive, the new interchange is expected to open its doors to the public in May 2007.