The dilapidated Wynant House in Gary, Indiana - the hometown of Michael Jackson - burned down on Monday night (9 January).
It is the second time in less than four days that fire has gutted an architectural gem in the area.
On Friday (6 January) firefighters were also unable to save Louis Sullivan's 115-year-old Pilgrim Church ( pictured below) in Chicago's historic Bronzeville neighbourhood.
It is understood the two-storey Wynant House, built between 1916 and 1917, was one of Wright's earliest attempts at affordable social housing.
The building, which stood in a rundown part of the former steel-producing area, was constructed by a Wisconsin prefabricated housing company called American System-Built Houses.
Rediscovered by a student 10 years ago, the abandoned family house was being renovated by a local historical group, in the hope it could become a tourist attraction.
Following the fire the future of the building is again in doubt and fire investigators are still seeking the cause of the blaze.