Feilden Clegg Bradley, Panter Hudspith, Julian Bicknell & Associates and Alec French Architects all feature in the shortlist for the prestigious prize.
The practices have been praised for their work on, respectively, Yorkshire Sculpture Park ( pictured), Art & Archaeology in Lincolnshire, The Hunterian Museum in London and the SS Great Britain in Bristol.
Judging chair Robert Winston said: 'Those chosen all show innovation, variety and excitement, and each is devoted to a special area with importance but with interest.'
The winner will be announced on 25 May at a ceremony at the RIBA.
The 2005 victor was the preserved coal mine Big Pit - National Mining Museum of Wales, designed by Powell Dobson.