The practice will eventually help deliver 145 of the 'flexible and sustainable' homes for housebuilding giant George Wimpey on the Oxley Woods site in Milton Keynes.
All of the homes at Oxley Woods, which come in 10 different designs and range in size from two- to five-bedroom houses, will meet the government's sustainability targets through the use of insulation, controlled ventilation and passive solar water heating.
Speaking about the project, Richard Rogers said: 'Our partnership with George Wimpey has given us an opportunity to take a fresh look at housing design.
'By working closely together, we have been able to develop an approach which links construction closely to design, giving real value to the homeowner.
'The scheme at Oxley Woods is highly flexible and sustainable and will, we hope, provide homes for a diverse community for many generations to come.'
Early guides put the market value of the houses at £199,995 for a two-bedroom property and £249,995 for a three-bedroom home.