Ranging in height from 22 to 26 storeys, the towers will house almost 600 apartments as well as providing space for leisure and retail units within double-height podiums.
The £75 million Harbour City scheme will have views across both the city of Salford and the canal basin - including landmarks such as Daniel Libeskind's Imperial War Museum and the Lowry Centre.
Designed for Manchester-based developer Peel, the development will also boast secure basement parking and links to the nearby Harbour City tram station.
A spokesman said: 'The four towers respond both to the views over the Quays and to vistas towards Salford, opening out the Quays developments towards the surrounding hinterland rather than turning its back as development has done in the past.'
Work is expected to start on site towards the end of next year.