The show will include more than 40,000 letters, models and drawings donated by the architect's family.
The exhibition will include detailed plans of Spence's famous Coventry Cathedral, and there is even correspondence between himself and toy-maker Lego, with the firm requesting permission to replicate his Gorbals tower blocks.
Spence's first post was at the London office of Edwin Lutyens, which had an important influence on Spence's own work. He went on to fight in World War II, and later set up his own company Spence, Glover and Ferguson.
The exhibition will be held at the Dean Gallery from 19 October 2007 to 11 February 2008.