The office has worked up the project despite having had been dogged by negotiations over Ken Livingstone's 'Safeguarding Wharves' policy.
The project, which is on an 8ha site adjacent to the high profile Silvertown Quays development, will transform the wharf, which was famous for almost 80 years as the home of sugar company Tate and Lyle.
The design includes 60,000m 2of offices, hotels, bars restaurants and leisure facilities in a mixed-use proposal with 1,474 homes, of which 35 per cent will be affordable.
Perhaps most importantly, the scheme - which requires the construction of a new DLR station - also takes in an operating aggregates wharf to encourage the use of the Thames in east London for freight.
EPR Architects' Brendan Phelan said: 'This scheme harnesses modern technology to provide an advanced, environmentally responsible and safe working wharf coexisting with other uses.
'Historically, and logically, the wharves ran from road to river in a linear pattern and in incorporating a new working wharf into the scheme we have sought to reintroduce this pattern.
'This gives river access at one end and road access at the other end and allows for the efficient operation of an essentially linear process,' Phelan added.