The architect has been asked to transform the British Library's Business & Intellectual Property Centre (BIPC) - a project which has received a £1 million cash injection from the London Development Agency.
The interior of the library has been largely untouched since it opened in 1997 - although Long & Kentish has been chosen to design a book and audio conservation centre on an adjacent site.
Once complete, the revamped BIPC will provide improved facilities for entrepreneurs as well as small and medium-sized enterprises.
The project includes proposals for a networking area and four workshop rooms.
It is understood the centre will officially open its doors in March this year.