Backed by developer Cibitas Investment, the 38ha scheme will create more than 370,000m2 of new homes - ranging from houses and duplexes through to large-scale apartments.
Hailed as a new 'urban quarter', the riverside development will also deliver a valley park, a primary school, offices, shops, bars and restaurants over the next 15 years.
David Shelton, a managing director at Cibitas, said: 'We will be introducing new uses, in a fully mixed-use sense, through the careful coordination of design with a robust financial model. This will ensure effective delivery of all the elements necessary to create a new part of the city.'
He added: 'Holt Town Waterfront is an ambitious project that will redefine urban family living in the UK. We hope this project becomes a flagship for the rest of the country.'
Already backed by CABE, the masterplan for the scheme was also worked on with Arup, Davis Langdon and GVA Grimley.