The Palast der Republic, in East Berlin - the former East Germany's toothless parliament - will be knocked down after a crucial vote went against the building yesterday.
The Modernist building was built in 1976 and, though having extremely limited power, was a key icon for many citizens living under the Communist regime.
All major parties in the Bundestag supported the demolition proposals, despite a growing movement calling for the building to be saved.
Artists have inhabited the space during the last 12 months and had campaigned - along with the Green Party and the ex-Communists - to save it.
The original building was designed by Heinz Graffunder and Karl-Ernst Swora.