Described as a stack of 'sliding glass-and-steel boxes', the 10,000m 2development will sit at the junction of Mosley Street and York Street.
The scheme, for Northern property giant Bruntwood, will be DCM's third major project in Manchester. The practice has already landed permission for a new office building at Hardman Boulevard and has nearly completed the Manchester Civil Justice Centre in Spinningfields.
According to DCM, this latest commercial development - which will have shops on the ground floor - will create a 'powerful focus when looking from Piccadilly Gardens down Mosley Street'.
Stephen Quinlan , the firm's UK director said: 'We are delighted to continue our involvement with Manchester's sustained renaissance and we look forward to delivering a first-class office building for Bruntwood.'
A similarly overjoyed Peter Crowther, Bruntwood's Director of Development, added: 'We have worked hard alongside our design team to achieve this positive decision. Having bought the majority of the buildings on York Street over the last five years, it's great to be in a position to press ahead with the construction of its focal point.'