Piers Gough's practice got the green light for the project last Friday at a council planning meeting.
The development will include significant swathes of office, retail and residential accommodation.
Around 50,000m 2of office space will be offset with around 1,000 apartments, a 150-bed hotel and a canopied piazza.
According to Gough, a new 'urban grain' is proposed for the Vaux site, assisted by the diversion and division of a major road running through the area - St Mary's Way - into two separate thoroughfares.
'This achieves the objective of integrating the roads into the urban fabric instead of segregating the roads and traffic from the development as it is now,' a practice spokesperson said.
'The new road layout will be more pedestrian-friendly and will be easily negotiable by pedestrians and cyclists at specific crossing points,' the spokesperson continued.
The scheme will also incorporate significant landscaping, green space and public realm work.
The council 'minded to approve the project', although there is a possibility that it could be called in by the Government Office for the North East because of its size.