The new 14-storey hotel will provide 340 guestrooms and suites, including a Ritz-Carlton suite and royal suite, 124 serviced apartments, and 70,000 sq ft of retail space and associated parking.
Gensler was appointed to design the scheme by Union Properties, a major player in the region's development market.
Gensler London managing principal Christopher Johnson said: 'We have presented an urban solution which reflects Ritz's longstanding tradition and complements DIFC's urban design, which was also by Gensler.
'We believe the hotel will enhance life in the inner city and give further credibility to the district,' he added.
The new Ritz-Carlton will be adjacent to the DIFC Gate building (also by Gensler) and linked to it by a covered retail arcade. Completion is schedule for late 2008.