The competition for the King's Quarter area, organised by the RIBA on behalf of Gloucester Urban heritage Regeneration Company, will see the delivery of 30,000m2 of new shops and 250 city-centre flats and apartments by 2012.
The scheme will also include the transformation of King's Square, the city's largest public space.
Gloucester Council leader Paul James said: 'This is a unique opportunity to help shape one of the most important areas of the city. King's Square is the premier public space in the city centre and people in Gloucester deserve a square they can be proud of.
'The redevelopment of King's Square has been talked about for years and people are desperate to see it happen. The design competition is the first stage in delivering on this aspiration.'
Selection will take the form of a two-stage process, which at stage one will invite expressions of interest. A shortlist of up to six teams will be drawn up and invited to produce concept designs.
Anyone interested in being considered should contact the RIBA Competitions Office for a preliminary briefing paper. This can be downloaded from www.architecture.com/competitions. The deadline for expressions of interest is Thursday 31 January 2008.