Described by historian Colin Rowe as 'the smallest monument in Cambridge', the semi-detached house will go on the market for the first time since it was completed in 1964.
The two-bedroom quasi-Brutalist building - a snip at £595,000 - is among only a handful of Grade II-listed post-war houses, and was used by Wilson as his home and studio.
Among the building's most impressive spaces is the double-height living room and its 'loggia-like' facade.
The house has retained most of its original features, including hardwood windows and exposed-concrete-block construction, made with crushed Abergele limestone.
In recent years the house has been rented out by Wilson, and specialist estate agent The Modern House admits the asking price 'reflects the fact that there is work that needs to be done to the property'.
Wilson, who remains best known for his British Library in London, worked widely in Cambridge, where he taught and set up practice.
His Pallant House Gallery - a new addition to a grade I-listed Queen Anne house in Chichester, designed in association with Long & Kentish - will appear in next week's AJ (AJ 20/07/06).
For more details about the Grantchester Road home visit www.themodernhouse.co.uk