The US-based Classicist will pick up the $100,000 (£56,000) Richard H Driehaus Prize, the most valuable in global architecture, when he visits the University of Notre Dame, Indiana, in March.
The annual award is handed out every year to reward the 'commitment to progressive ideas that advance Classical ideals'.
Greenberg's work in Classical architecture has won him many commissions from establishment figures in the US, ranging from Hollywood actor Harrison Ford to former secretary of state George Schultz.
He carried out many commissions for the State Department, a job which followed in close succession from the 1989 Shoah Memorial in Battery Park, New York ( pictured).
According to the citation, this work at the State Department, which included the ceremonial Treaty Signing Room, produced a 'character in which Thomas Jefferson, the first Secretary of State, would feel at home'.