The long-term architectural activist claimed yesterday evening that the city was in danger of becoming a 'clone city'.
Speaking at a conference of World Heritage Cities, he insisted that the Scottish capital must 'resist commercial pressures' to overdevelop.
These comments will infuriate the city's architectural community, who have become increasingly frustrated by the power and influence wielded by world heritage administrators.
He called on conservationists, architects and environmentalists to work to 'nurture and protect' the Scottish capital's 'unique' character.
However the Prince did, unusually, claim that he approved of Edinburgh's historic blend of old and new design and praised it as an exemplary model for inner-city living.
For further analysis of the Edinburgh debate see today's AJ.