Part of the £45 million development on the banks of the River Lagan, the 80.5m-high Obel Tower will become Northern Ireland's tallest residential building.
The skyscraper will house 182 apartments, including four penthouses and 59 one-bedroom apartments, with two levels of basement car parking.
There are also proposals for a 144-bed eight-storey hotel, a 3,800m 2office building, a bar and a restaurant.
Broadway Malyan's Peter Vaughan said: 'Obel represents a significant stage in the regeneration of the Laganside area of Belfast.
'This is our first major project in Northern Ireland and we are looking forward to creating a new residential, commercial and retail area for this part of the city,' he added.
The practice has also been appointed to design the public piazza and community areas of the scheme.
Work is due to begin on site in April 2005.