The project, which will feature four-, six- and seven-storey apartment blocks, is being billed as an 'instrumental' first step in helping to reconnect the long neglected area of the city with the existing urban fabric.
Designed for the Charing Cross Housing Association, the development includes a mix of flat sizes - going up to four-bedroom apartments - available to either buy or rent.
A spokesman for the practice said: 'The Garnethill site is very constrained, but has spectacular views across the city to Park Circus and the spires and towers of the West End.'
He added: 'The cluster of buildings adds up to a stimulatingly rich composition of rectilinear forms, given a sculptural quality by the combination of glass, render, metal and timber, reinforced by vertical banks of prominent balconies.'
Work is due to start on site in December and the first tenants are expected to move in during November next year.