The Stirling Prize winner has decided to relinquish his position after six years, and will be succeeded by AF Trustee and internationally renowned glass artist Brian Clarke.
Although Clarke is an artist, not an architect, he has worked alongside some of the biggest names in architecture in his career, and was brought into the AF by Alsop himself five years ago.
Clarke, who has collaborated with Norman Foster, Zaha Hadid and Future Systems as well as Alsop, is also chairman of the estate of Francis Bacon, and the Winston Churchill Memorial Trust.
Speaking about his new role, Clarke said: 'I will be looking to continue the work that has already been happening.
'Richard Rogers was chairman for a long time and Will dedicated six years to it, which is a big chunk of your life. I hope to pick up from the work Richard and Will have done, and add to it.'