The mixed-use development will be the first of its kind to be built in the port town, and will act as a catalyst for major regeneration in the area.
The focal point is an 80-storey tower that will include residential, retail and conference facilities in addition to its primary function as a commercial office building.
The helical scheme will provide more than 100,000m2 of office space, with a 250-bedroom five-star hotel occupying the top 21 storeys. The hotel will also include 30 luxury apartments as well as a swimming pool with views over the Indian Ocean.
Three further towers of varying heights will 'echo' the design. Arranged around a lake, these buildings will include residential apartments as well as retail space.
Project director David Kingdom said: 'This is the first step in developing a large swathe of reclaimed land at Karachi Port, which is a promising area of prime commercial and residential development.'
The scheme is scheduled to begin on site in April.