The practice - in collaboration with Balfour Beatty - has been appointed as framework partners to deliver the first phase of the government's Building Schools for the Future (BSF) initiative across the area.
The first phase of the project includes the refurbishment of a number of existing schools and the construction of further new schools in the city, including three special educational needs high schools.
The total value of the two-phase BSF programme in Manchester is in excess of £350 million. It involves 35 schools and more than 10,500 pupils.
The Aedas/Balfour Beatty partnership is one of two teams signed up by the council for a period of three years, with an option to extend the appointment by a further two years.
Brian Johnson, director at Aedas Manchester, said: 'Manchester is undergoing major regeneration in several areas of the city and the provision of high-quality education is seen as the cornerstone of these developments.
'This is a significant opportunity to make a major contribution to these areas and provide Manchester with more high-quality, sustainable education facilities,' Johnson added.