The 100,000m2 Adige City, which will overhaul a former industrial area on the outskirts of Verona, will mark the 73 year old's Italian debut when it starts on site next year.
Describing the scheme, a spokeswoman for the city, said: 'The Anglo-Florentine architect's intention is to help regenerate the city by creating spaces with people's needs in mind, balancing public and private needs, making it a vibrant, active and sustainable place.
'Rogers's creation will be fundamental in leading Verona South into its position as a key player in the national economy by providing a bridge between Lombardy and Veneto, and between Italy, Europe and the rest of the world.
Among the other buildings proposed as part of the 'city within the city concept' will be new 'green' public spaces, office space, a hotel, homes for 3,000 people and retail areas.
Although the practice, now know as Rogers Stirk Harbour, has previously worked on masterplans in Italy - and is also currently drawing up plans for the new Capodichino Underground Station in Naples - the Adige City scheme is expected to be the first in the country to be fully complete.