Architects who are fascinated by non-orthogonal architectural forms regularly feel the lash of knotted cords wielded by white-faced monks of the Old Modernism. One of the big complaints from the Calvinists is that their forms are either whimsical and irrational, or self indulgent and artsy, having foundation in neither science nor logic.
So, one of the big things for the Non-Orthog has been the development of algorithms for generating 'objective' forms. No, not wacky forms but forms generated by the studied manipulation of complex mathematical equations. Which are a tad more sophisticated that that ninety degrees in all directions stuff beloved by the Old Dims.
The Non-Orthogs also point to the gradual emergence of bespoke mass production. Stir in the mathematics of such things as planar quadrilateral meshes and CADCAM and you have people such as Skylar Tibbits and Marc Fornes at the SJET blog for which I'm grateful to Marcus Fairs at that terrific blog Dezeen. As is almost always the case with this kind of site, the links are as interesting as the main stuff.