Mingling with schemes by the likes of Will Alsop, Ian Simpson and Studio Egret West, there will now be a development likely to mimic Dorset's famous Poundbury.
The unlikely appointment will see the Prince's masterplanners working on a site adjacent to the Gorton Monastery.
The Monastery Village scheme, for English Partnerships, will consist of around 60 larger family houses on land which has been derelict for almost a decade, and a mixed-use development adjoining the Monastery building itself ( pictured).
At an event launching the scheme on Monday, Hank Dittmar, The Prince's Foundation chief executive, said his organisation had taken on the development because of the heritage angle.
He said: 'The Prince's Foundation only works on a small number of projects each year, selected on the basis of the educational opportunity they offer.
'In the case of Gorton Monastery we want to demonstrate how new building adjoining a sensitive heritage site can add to the value of the heritage asset rather than detract from it - providing a real catalyst for regeneration.
'We hope that the communities of east Manchester will reap rewards from this building project long into the future - and that housebuilders working in similar, sensitive sites will see this as a learning opportunity.'