Organised by the RIBA Competitions Office, the contest hopes to attract multi-disciplinary teams from around the world to deliver 'an inspirational quality design' for Stoke's city centre.
The council and its regeneration partners want to create 'a vibrant and prosperous city centre' which will become 'the heart, soul and mind' of the Potteries.
Over the next 10 to 15 years more than £1.2 billion worth of investment is expected to be pumped into the Stoke area.
The city's drive to transform the public realm emerged from recommendations in the City Centre Development Framework and Investment Plan.
According to the competition brief: 'The challenge to competitors will be to address such issues as unified pedestrian movement corridors throughout the city centre, and the enhancement of the 'sense of place' which will aid orientation when moving through the city.
'This network of streets will link a series of revitalised public spaces and squares that will be transformed into new areas for relaxation, market trading, events and performance.'
The mayor, Mark Meredith, said: 'This competition is a tremendously exciting opportunity to place Stoke on Trent City Centre on the international stage and to declare our determination to create a transformed city Centre of which we can be proud.'
Further details about how to register can be found at www.architecture.com/competitions