Titled Leonardo da Vinci: Experience, Experiment and Design, the much-anticipated exhibition will showcase more than 60 original drawings and will feature innovative computer graphics to 'illuminate Leonardo's vision in a new way'.
Practice director, Paul Williams said: 'The animation concept stems from thinking of drawings as a static window on to a dynamic thought process.
'With the computer sequences we have tried to give an indication of the kind of animated visions that might have been in Leonardo's inner eye as he explored the natural world, and of which his exquisite drawings capture the essence.'
Williams worked closely with animator Cosgrove Films - of DangerMousefame - and the curatorial team on the ground-breaking exhibition.
'It was crucial that the computer animations did not dominate the original drawings, so we decided on projections rather than plasma screens as they are softer and more ethereal,' added Williams.
As well as the drawings, which were taken from Leonardo's notebooks and from separate sheets, there will be large-scale models of Leonardo's designs displayed around the museum.