The practice - in collaboration with environmental designer Studio Engleback - was
selected by developer Wharfside Regeneration (Devon) following a competition to draw up a masterplan for its North West Quadrant (NWQ) scheme.
The mixed-use scheme, which will include up to 800 residential units and a shopping centre, has also been tasked to create a 'northern gateway' to Plymouth with a 'strong sense of place and urban form'.
S333's winning entry has four distinct neighbourhoods within the district centre, knitted together by a network of courts, streets and parks.
Dominic Papa of S333 said: 'With amazing views over to Plymouth city centre, and with Derriford Hospital, Tamar Science Centre, the International Business Park and Forder and Bircham valleys attracting people to the area, there is a real opportunity for a vibrant, mixed-use urban quarter.
'Our concept for healthy landscape and living is a holistic approach to urban design that will generate the necessary intensity that will help maintain social and economic sustainability.'
Wharfside Regeneration and S333 are expected to apply for planning permission on the site by the end of the year.