Rogers was expected to carry forward his masterplan to revamp the former industrial Haringey Heartlands site, but has now pulled out of the project due to the practice being over-stretched.
'Therefore we are unable to provide adequate resources to continue with the development of the original masterplan study for Haringey Heartland.'
The decision will come as a massive blow to both National Grid Property, the developer, and Haringey Council, who were expecting one of the biggest names in architecture to be working alongside them.
The scheme has been dogged by setbacks ever since the original designs were put forward in 2000, as landowners and developers became reluctant to invest in what was deemed as too grand a scheme.
Phil Edwards, Strategic Sites Manager for National Grid Property, said: 'Although it is disappointing that RRP is no longer able to be involved in this project, we thank them for all their hard work to date.
'We can confirm that we will shortly be appointing a new masterplanning architect who will be able to take the Haringey Heartlands regeneration programme to the next stage. I am confident that this won't cause any delay to the progress of the project.'