In a thinly disguised attack, the Prince criticised the rush to build seen in many of the region's cities.
As he received an award in the Saudi city of Riyadh for his lifetime commitment to his work with architectural heritage, the Prince outlined his concerns about the growing internationalisation of architecture.
'What I find so deeply depressing frankly, when going around the world, is you might as well be in the same place,' he told the gathered dignitaries.
'I want to go knowing I'm in Saudi Arabia or Egypt or Britain,' he added.
The comments at the King Abdul Aziz Historical Centre are sure to anger and frustrate many of the British practices who have found success in the region.
In the same speech Prince Charles also condemned the country for the widespread 'predominance of the car'.